This is the short list of the most common foods that conflict with Syrian Rue. Rather than deciding that you will go about life without eating certain foods, you ought to embrace the fact that certain foods are not good when mixed. For example, beer and milk. You can drink both beer and milk – but not at the same time. Don’t suppose that you must give up beer because you drink milk every morning for breakfast. Also consider smoking rue, the dietary restrictions are relaxed a little when smoking rather than eatng rue. http://SyrianRue.org/Smoke. At a minimum, read about smoke as part of the read about diet because that page also mentions a bit about dose and effect of rue..
2022 and beyond re-search will continue to be re-sought out by looking at what has been looked at before. After all these years I continue to discover. I look back over the years and remember tough nights of watching Syrian Rue seeds floating in the vomit when learning what not to eat with rue. I watched people taste it for the first time and say, “This isn’t so bad”. They didn’t go to the lengths I generally do to avoid the taste. I had stopped working with tea because of the taste. We do not eat aspirin for the taste of it so I began researching that area more. Extractions boiled for 2 hours were stronger than room temperature extractions over night. Water extraction is not necessary, eating raw seed works well. Eating raw seed takes about 50 minutes and a tea is about half of that.
After a few seasons of eating raw seed. I like to boil water extract to a thick tar and take a small pea sized amount. This water extract can also be dried to a powder. A small pea size is a little more than heaping spooonfull of seed by equivalence. The pure alkaloids are even more concentrated than that so know what a dose is. Extracts are made different ways. Too much is a sickening experience and could be dangerous. Eating pure alkaloids must be done carefully.
Large doses are being explored more. 1 teaspoon of seed is enough to have an effect as an MAOI. 2 heaping spoonfulls boiled is a very large dose, or an overdose. At 4 heaping teapoons my ears were ringing in 20 minutes and I felt my blood pressure rise and puked 5 times in the first hour. That might have caused an abortion for a pregnancy. That was too much, an overdose. Deep breathing and staying on the bed was what I needed. I was thankful for the learning experience which had very long “Rue Trails” for 16 hours. I wont repeat it intentionally – such an extreme is not helpful.
Increase your dose slowly and stop increasing at slight nausea vs. extreme sickness. I like to be on my feet so I don’t eat so much and I nearly never get sick. I considered that if I had accidentally combined a dose like that with high levels of tyramine death or coma could be conceivable. I remember reading in Shulgins books his notes on rue doses and journaled about the sickness then raised the dose the next day and journaled even more sickness then raised the dose and journaled the worst sickness and thought it was intriguing why someone would eat more of what makes them sick? Here I am doing the same thing and the object is to do this without getting sick. There is no tolerance with rue therefore you never come to need more to reach the same effect due to frequent use. After years of wanting to understand what this fundamental beta carboline is about, a level teaspoon which has a subtle effect is where I settle.
I have been doing experiments with Caapi. Yellow caapi and red Banisteriopsis cappi have the same primary alkaloid as Syrian rue. Tastes like molasses to me. I started to view the taste of Syrian rue rue as terrible due to the psychosomatic preconditioning that i had from a bad experience with Rue. Now I am eating caapi until it becomes disgusting and my mouth waters from nausea, then ride it down for the next 12 hours for a beautiful experience without any vomit. Caapi and rue do have very similar effects. Caapi tastes good to me, perhaps after my first train wreck dietary bad combo story with Caapi then the taste of cappi will give me chills and gag reflex response from psychosomatic trauma preconditioning triggered at the memory of the taste. I hear others say rue doesn’t taste that bad and I am seemingly recovering from my own traumatic run ins with rue because when my diet is right, 2 heaping teaspoons boiled for 2 hours and put into a shot glass has been done, that’s right near where the visual phenomena with “Trails” dose begins. That’s a big dose. Its best to take a dose that size in two portions hours apart. There is such a thing as too much and too little with an MAOI.
Its difficult to measure milligrams by eyeballing it. I found a way to find a comparable dose between Rue and Caapi which is by large doses. Eat caapi until visuals begin any less than that is an undetermined amount of milligrams of the alkaloids. Let the experience wear off then try to match the effects with Rue or Caapi the next day or time and compare the differences. The is where my path of research was. I will be taking notes down the path of starting at the dose of “Trails”. Both Rue and caapi will produce the effect. In the end, the verdict is that the medical effects are indistinguishable. Rue is far less expensive and much simpler, as Caapi vine must be shredded and boiled then the extract reduced to tar. Eating seeds will suffice with rue. Rue doses are smaller than caapi. A pea size of rue tar extract equals a teaspoon of caapi extract. Rue glows in blacklight and caapi does not. These were the most distinguishing difference between Syrian rue and Caapi. Caapi is also called Ayahuasca Vine.
Entering into May 2022, due to the recent USDA confiscations of this http://SyrianRue.org/Legal seed on all international orders, non US vendors only sell concentrates made from the seed and not the actual seed to the United States. Therefore I momentarily worked with pure alkaloids more. However I prefer seed and obtain it when I can. If any readers can contribute helpful information about where to http://SyrianRue.org/Purchase Syrian Rue seed in the United States, please reach out to me on the http://SyrianRue.org/Conact page.
While eating Syrian Rue, avoid aged cheeses such as Parmesan, Chedder, Blue Cheese, Swiss, Gouda, Feta, Brie, Gruyere, and Emmental. Cheeses such as American cheese, Cottage Cheese, and fresh Ricotta are not aged and need not be avoided. Avoid aged, smoked or preserved meat like Beef Jerky, Pepperoni, Mortadella, Salami, Shrimp paste, Pickled herrings, or salted Cod. Do not eat raw yeast, nutritional yeast, or any preservatives such as MSG which is a Yeast Extract. Do not eat fermented tofu or soy. Fermented soy is found in some vitamin supplements in large amounts.
The substance to avoid is tyramine. Very small amounts of tyramine will not make you nauseous or give you a headache/migrane headache, but large amounts will. Tyramine is poison to everyone, but the levels of tolerance to tyramine vary from person to person and from time to time. The berries of the mistletoe plant contain poisonous amounts of tyramine to all people at all times. Although Syrian Rue is an antidote to other poisons, it lowers your tolerance for tyramine causing you to become more sensitive to it. Poisonous tyramine is found more in old, mishandled, or damaged food because many food sources contain the beneficial amino acid tyrosine. Tyramine is created by bacteria that decarboxylate the tyrosine into poisonous tyramine. It allegedly can be created by bacteria in your own bowel after eating foods rich in tyrosine, it definitely can be created by bacteria before it enters your body.
Begin digression on Cyanide:
On the topic of poison, consider cyanide which, without an antidote, causes death by asphyxiation in large amounts and some amount of cellular death in small amounts. Corn, sudan grass, sorghums, cherry, apple, broccoli, and peach may accumulate large quantities of cyanide – mostly in leaves and seeds. 3.7 pounds of Lima beans contains a lethal dose of cyanide. The accumulation of cyanide in certain plants occurs when they are injured or drought stressed. The good news about cyanide poisoning is that the simple antidote is garlic. Garlic and Shallots do some magic to mineral sulfur making it water soluble so that the presence of sulfur in your blood will react with cyanide, destroying it. Garlic is essential prior to drinking Morning Glory tea.
A cyanide ion combines with sulfur to form thiocyanate. Curiously the hepatic enzyme, rhodanese (properly called thiosulfate:cyanide sulfurtransferase), also converts cyanide to the far less toxic thiocyanate. An enzyme of the rhodanese superfamily is ubiquitous to all life just as Dimethyltryptamine and Water are found in all living organisms.
Garlic and Shallots are natures silver bullet against cyanide which occurs in over 100 plants. The biosynthesis rate of endogenous rhodanese enzymes is coded in your DNA – just like your MAO and the many other metabolic enzymes that you naturally biosynthesize. Your own enzymes will manage small amounts of cyanide. For large amounts of cyanide in the body – you will need an antidote.
You COULD ingest more rhodanese enzymes that were cultured in large quantities. Microorganisms are generally used as sources for industrial enzyme production. The enzyme Lactase, which aids in the digestion of milk, is produced with Escherichia coli. The Microorganism Sulfobacillus sibiricus is used to create rhodanese enzymes. Sulfur in your blood, obtained predominantly by eating Garlic (Kale has some sulfur also) does the SAME thing as pharmacutical rhodanese enzymes. They both destroy cyanide, turning it into thiocyanate. Sulfobacillus sibiricus sure seems silly when we can just eat Garlic.
Hydroxocobalamin, a manmade analog of Vitamin B12 called B12a, will nonenzymatically react cyanide into non-toxic cyanocobalamin. Cyanocobalamin is a form of Vitamin B12 and even more ideal than creating useless (and mostly harmless) thiocyanate in your blood. Hydroxocobalamin is a more effective form of Vitamin B12 for many people, as it is more readily available in the body.
A final note on cyanide, boiling for long periods significantly eliminates much of it into the air before it enters your body. Raw flax in larger amounts can cause a belly ache and boiling it releases most of the cyanide. So dont fear a super food like flax merely because there is poison in it.
End of digression on cyanide.
Back on the topic of the poison that Syrian Rue and Caapi will not tolerate which is Tyramine. Tyramine is also created by plants – not just bacteria.
You dont want to become a religious nut about your diet and abstain from a mostly harmless dash of cinnamon or from ALL tree nuts in an attempt to eliminate ALL tyramine from your diet when your body can metabolize a little. Brazil Nuts and Hazel nuts are far worse than Almonds or Cashews which I frequently combine with Syrian Rue to no ill effect. Avoid large quantities of: spinach, cabbage, tomatoes, italian flat romano beans(other beans are OK), pineapple, dates, snow peas, avocados, raw onion, papaya, eggplants, figs, beets, olives, broccoli, red plums, kim chee, prunes, raspberries, peanuts and peanut butter, Brazil nuts, walnuts, coconut and coconut water, ginseng, licorice, cinnamon, anise, curry powder, hot paprika, nutmeg, beer and wine.
Some of the aforementioned foods are safe in small quantities, but they are all known to have some tyramine. On a mild dose of Syrian Rue I ate half of a large papaya and experienced no nausea. Small doses of rue make for easy daily use. For example there are many varieties of spinach, some contain low levels of tyramine that will not be a problem unless you eat too much of it. Be careful with spinach. Eat kale. Most varieties of spinach have a high tyramine level. Additionally,
Begin digression on Oxalic Acid
Spinich is very high in Oxalic Acid which is an anti-nutrient binding to elements used and needed in the body causing them to be expelled in urine. It does this to a degree that it immediately causes damage to mitochondria and other areas. It is a poison. It is common in leafy greens.
It seems better to eat Kale rather than Spinich however foods high in oxylate can be chopped and boiled with baking soda to destroy Oxalic Acid, cooking it alone has no effect on oxalic acid levels. Cooking only reduces cyanide.
End digression on Oxalic Acid
I have consumed 2 beers on a medium dose of Syrian Rue to no ill effect, maybe mild bloating. In general they do not mix. Expect different variety of wine and beer to contain different levels of tyramine. Drink tequila or take a break. My very worst ever experience on a large dose of Rue and a diet that was strictly flawless except with a multi-vitamin pill that upon detailed inspection concluded an ingredients list with “may contain fermented soy”. I took the vitamin pill at 12:00 and the large dose of Rue at 5:00 and was extremely ill by 8:00 – the uncontrolled violent vomiting and dry heaves subsided late into the night. There was no warning about mixing the vitamin with an MAOI – but it was a bad combo.
One time i was nauseated by a curry chicken dinner that mixed with my gut full of syrian rue. Unlike most other bad food reactions that dissipate within a few hours, i remember feeling the curry/rue combo pass through me for 2 and a half days. In 2020, while eating rue with a friend we were offered a curry meal. I declined and told him that curry doesnt mix. He is like me in the fact that he breaks all the rules and must see for himself if a thing is true. It was interesting for me to confirm the seriousness of curry because pinpointing the bad food reaction is not easy. For example – it could have been rotten chicken covered by the taste of curry – but the problem was certainly the curry. Curious curry. What is curry? It varies depends on who makes it. Curry often contains bouillon broth, which unless freshly made which is rare, contains Yeast Extracts or MSG as a preservative which does not mix with Syrian Rue. A complete meal with all good ingredients becomes sickening when bouillon broth cubes or powders are added therefore eating at restaurants becomes a gamble on large doses.
Alcohol does not conflict with Syrian Rue – yeast in beer and wine does. A slice or two of yeast raised bread is ok to eat because most yeast dies during baking leaving behind none or so little that bread has never been a problem. What I have discovered with beer is that with some brands i can drink 1 or 2 beers and not get sick and with other brands, just 1/3 of a single beer is all i can handle. It has more to do with the brand of beer you are drinking than with the amount of Rue that you take.
Strawberry seeds contain tyramine. Do not eat a large bowl full of strawberries with Syrian Rue, likewise with raspberries. Knowing that the strawberry and raspberry seed that is to blame and not the flesh is interesting. Banana is 100% tyramine free – however there is tyramine in the strings under the banana peel – so peel it proper and complete. The small dark end of a peeled banana opposite from the stem also has a tiny amount of tyramine, only eat the yellow flesh which is 100% compatible with Syrian Rue.
Food that is ideal is 100% tyramine free – Such as:
Fresh chicken, eggs, fish, beef, white bread, wheat bread, rye bread, English muffins, crackers, bagels, hot and cold cereal, cream of wheat, rice, cooked dried beans, peas, and lentils, all pasta, apple, banana,mangoes, blueberries, melons, melon blossoms, spaghetti, egg noodles, rice, corn, asparagus, carrots, pumpkin, squash, zucchini, cooked onion, bread fruit, American cheese, ricotta, cottage cheese, cream cheese, eggs, canned salmon or tuna fish, tuna salad, milk: whole, 2% or skim, salt, chives, sugar, maple syrup, honey, and salad dressing made from olive oil and lemon juice. Baby kale can be cooked or in a salad with Hibiscus flowers. Potatoes, Sweet potatoes, Yams, Yucca, and breadfruit are all good. Pistachios, Cashews, and Almonds have always been good although they have trace amounts of tyramine. Bananas are especially good in the event of vomiting for the potassium. Eggs are also good to replace protein. Not all proteins are created equal – eggs are the best: https://www.aeb.org/food-manufacturers/why-eggs/white-papers/real-eggs-not-all-proteins-are-created-equal
Poison is everywhere. White potatoes have the poison solanine. Cooking them destroys most of it. Sweet potatoes are far more nutritious and do not contain the poison so they are good to eat raw. Sugar and carbs increase with cooking. One cup of raw sweet potato has about 114 calories, 26.8 grams of carbs and 5.6 g sugar, whereas one cup of baked sweet potato has about 180 calories, 41.4 g carbs and 16.9 g sugar. Yucca is also a far more nutritional choice than white potato – and all of them are good with Syrian Rue. Perhaps you were unaware that white potatoes can kill you – see the following link:
https://www.smithsonianmag.com/arts-culture/horrific-tales-of-potatoes-that-caused-mass-sickness-and-even-death-3162870/ Boiled green bananas taste like white potato and they are much more nutritious. Very green bananas when they are boiled taste similar to a white potato whereas almost yellow bananas are sweeter and even more delicious – boil them in salt with the peel on until it splits and the otherwise unpeelable unripe banana easily slides from it’s skin. There is no anecdote for solanine poisoning. Diazepam is used to help with solanine poisoning. Diazepam is marketed as Valium so when you buy white potatoes remember to pick up some Valium. If the pharmacist refuses to give you Valium use the natural and nearly identical Valerian Root – here is the history of Valerian root: https://www.world-of-lucid-dreaming.com/valerian-root-dreams.html#:~:text=During%20the%201800s%20valerian%20was%20widely%20used%20in,the%20%22%20Valium%20of%20the%2019th%20Century%20%E2%80%9D.
The word valerian derives from the Latin word valere, which means “to be in good health.”.
Beware of Yeast Extracts, (the yeast of the Pharisees). Yeast extract is the common name for various forms of processed yeast products that are used as preservatives. Monosodium Glutamate (MSG) is the most well-known yeast extract. MSG side effects range from headaches and nausea to heart palpitations or chest pain in about 14% of Americans. Syrian Rue amplifies the effects of yeast extract poisons.
Due to the common knowledge that MSG is bad for your health, corporate chemists/scientists have created other yeast extracts with lesser known names. The general method for making yeast extracts for food products is to add salt to a suspension of yeast, making the solution hypertonic, which leads to the cells shriveling up. This triggers autolysis, wherein the yeast’s digestive enzymes break their own proteins down into simpler compounds, a process of self-destruction. The dying yeast cells are then heated to complete their breakdown, after which the husks (yeast with thick cell walls that would give poor texture) are separated. When consumed with an MAOI such as Syrian Rue, it will raise your blood pressure and may produce nausea/vomiting in some cases.
Yeast extracts are found in various condiments and seasonings and should be avoided, those to be avoided includes but are not limited to bouillon cubes/powder, meat tenderizers, dry packaged and canned soups, gravy, sauces, stew mixes, instant soup dry powder bases, Soy and Teriyaki Sauce. Some vitamin supplements contain brewer’s yeast or fermented soy and should be avoided.
Yeast and yeast extracts and their synthesized relatives, aka “preservatives” are poison. Newly marketed in 2022 as “All Natural Mushroom Extract”. Their poisonous effects are amplified by an MAOI.
Technically, Syrian Rue is a reversible MAOI also called a RIMA. Alternatively, pharmaceutical MAOIs are irreversible which means they covalently bind to the MAO enzyme rendering it permanently deactivated and cannot be restored until the body replaces the enzyme through new enzyme synthesis. The rate of MAO synthesis occurs according to DNA codes. Reversible MAOIs like Syrian Rue can be displaced from the MAO enzymes so that the risk from tyramine is significantly reduced. Many sources of information referring to general MAOI food interactions are specifically with regard to non-selective irreversible pharmaceutical MAOIs such as Parnate and Nardil, applying somewhat less or not at all to Syrian Rue which is much safer than pharmaceuticals. RIMAs are displaced by tyramine on the MAO enzyme therefore tyramine can be metabolized so a hypertensive crisis is not easily encountered using Syrian Rue like it is using pharmaceutical MAOIs. Using Syrian Rue as an MAOI, tyramine is more likely to produce nausea than a hypertensive crisis.
I used Syrian Rue many 100’s of times, probably 1000’s of times between 2014 and 2020 without experiencing sickness. It is not very difficult to eat a Syrian Rue compliant diet and with all of this information available, bad experiences will be rare but not altogether eliminated. Even with dietary knowledge – accidents happen. On one occasion I ate a large amount of processed de-shelled sunflower seeds that contained tyramine. Although Sunflower seeds contain no tyramine, they can spoil. Although I opened the bag and it was within the freshness date – that bag was spoiled and contained enough tyramine to make me sick.
Do not eat anything other than very fresh food. No dried fruit and just about all prepared packaged ‘meals’( canned, frozen, or dry packaged ) contain tyramine as yeast extracts. Products should not be used if they are close to the expiration date.
Alexander Shulgin proposed that harmala itself caused nausea. Even on a perfect diet, with a high dose of syrian rue there are frequently a few waves of slight nausea. Smoking cannabis seems to help cure mild nausea. Drink plenty of water. Being dehydrated makes it impossible to vomit if your body needs to and drinking water induces vomiting when you are already dehydrated making it hard to drink more. Be extra conscious to drink water when eating Syrian Rue. Drink extra water which will make a purge easy if necessary.
Diabetics: Eat a small piece of bread and fruit juice 60-90 minutes before taking the Rue and keep fruit juice handy. A 2007 study suggests that Syrian Rue acts like thiazolidinediones, however, harmine does not cause significant weight gain or hepatic lipid accumulation. Syrian Rue is used to treat diabetes. Type 2 diabetics might be able to achieve a reversal of their condition from the harmine in Syrian Rue.
Pregnant Women: Syrian rue contains uterotonics. You should definitely not use LARGE AMOUNTS Syrian Rue in later stages of pregnancy as it may induce labor. Extremely large doses(50 to 150grams) will cause an abortion due to the release of prostaglandins. 1.5 grams is enough to activate DMT and that amount is safe. I know a woman who used Ayahuasca many times during her pregnancy and she has a beautiful healthy baby girl. Rue only becomes dangerously to pregnancy in very high doses which are used to intentionally abort a fetus.
Fasting prior to Ayahuasca
This is a curious and unexpected finding. I do not recommend Aya for someone who is many days into a fast. In one case somewhere near the 15th day of nothing but water, first the Syrian Rue was consumed. The effects of the Rue were enjoyable, then an extract from either Chacruna, Chaliponga, or Mimosa Hostillis was consumed slightly more than an hour after the rue and it became a difficult and uncomfortable experience. Eat compatible food or only skip a single day of eating is my recommendation.
There is a fine line between Plants, Medicines, and Drugs – a person could argue that all 3 are one and the same thing. Even the question of what is natural is open to debate. Water can be created synthetically by combination of hydrogen and oxygen, is it then unnatural water? I would say no. When natural organic elements are combined to create a molecule which cannot happen without the hand of mankind the product can range from almost natural to completely unnatural which is further discussed below.
Pharmaceutical irreversible MAOIs combined with certain other medicines is a certain recipe for hypertensive crisis and possible death. Although the dangers of a reversible MAOI like Syrian Rue are far less – they still exist. Do not combine with SSRI antidepressants and dramamine. Decongestants and antihistamines are untested by myself – both are generally not combined with an MAOI but i dont know if the conflict is only with irreversible MAOI’s. Dont mix them is the rule – any rule breakers out there let me know what happens. I sometimes carefully break rules to find more understanding, so I mixed a large dose of syrian Rue with 2 cups of coffee which most information sources say should not be mixed with Rue, the stimulating effect was seemingly increased. 2 cups was not dangerous. I mix them frequently. Mixing Pharmaceutical irreversible MAOIs is more dangerous than mixing Syrian Rue however an understanding of the metabolic similarities is helpful.
Wait at least 3 weeks after taking selective serotonin reuptake inhibitors (SSRI) before starting with MAOIs. This includes antidepressants such as the herb kanna (Sceletium tortuosum) and pills such as paroxetine (Seroxat), citalopram (Cipramil), fluvoxamine (Fevarin) and sertraline (Zoloft). Zoloft and many of these have side effects which cause impotence in men. Ironically, Syrian Rue is known to be an aphrodisiac. Rue also mixes safely with other powerful nitric oxide boosting plants like watercress which have a side effect causing erections in men. I have no experience with mixing kanna I’ve heard that Rue and kanna is a bad mix, some say you should quit kanna for weeks before rue. It’s recommended to wait 6 weeks after fluoxetine (Prozac), as Prozac has been blamed for at least 1 death in combination with Ayahuasca which is a reversible MAOI just like Syrian Rue. Prozac is the result of politics in medicine because the FDA banned the natural amino acid, L-Tryptophan, which was the rival to Prozac. It was banned via intentionally misrepresenting the truth, https://lightparty.com/Health/FDABan.html
Additionally, the FDA overlooked 27 deaths during clinical trials when approving Prozac, https://ssristories.org/the-story-behind-prozac-27-deaths-during-clinical-trials-ignored-denied-and-lied-about-whittle-wieland/
The FDA would blame Ayahuasca for the deaths when in fact the undeniable evidence lays the blame on Prozac. Do not use Syrian Rue or Ayahuasca with Prozac. The FDA is responsible for many deaths over Prozac.
Logic would conclude, that however rare Ayahuasca based MAOI deaths are the same principle alkaloid present in banisteriopsis caapi(Ayahuasca vine) is also in Syrian Rue and therefore I would presume that such an accident, unto death, must be possible equally with Syrian Rue as with Ayahuasca.
I have seen Syrian Rue successfully mixed with Xanax and Klonopin resulting in no negative interactions. I have seen stimulants mixed with Syrian Rue, but not to a degree that seemed dangerous.
With specific regard to Dextromethorphan(DXM), which is a cough suppressant and a disassociative. On the Robotussin bottle it says “Warning do not use with an MAOI”. Even when eating Syrian Rue I still tried the cough medicine – there was no sickness or hypertension of any kind. I only used the cough medicine in the prescribed amount – or possibly even slightly less than the prescribed amount. Maybe if i would consume the whole bottle of cough medicine it would react with the Rue. The DXM came with the warning against MAOI’s and it was a safe mix with Syrian Rue and a vitamin pill that MAY contain fermented soy came with no warning and caused violent vomiting when mixed with Syrian Rue. I do not recommend mixing psychedelic amounts of DXM for its disassociative effects along with Rue – i wouldnt try it but that doesnt mean anything – let me know how it goes if you try it. DXM is fully unnatural in that the molecule, nor any molecule even close to DXM exists in nature. DXM belongs in the same category as Ketamine and PCP(Angel Dust) based on the molecular structure and disassociative class, they all have quite different effect and some knowledge of spiritual and physical connection may be gleaned from them, long term use seems unwise. The best article I have ever seen that groups neurotransmitters based on molecular structure is https://en.m.wikipedia.org/wiki/List_of_psychedelic_drugs
With Specific regard to Mescaline, Syrian Rue will enhance the effect. Alexander Shulgin commented that the threshold dose of Mescaline is 200 mg so 100mg being sub-threshold will have no effect unless taken together with Syrian Rue which stops MAO from metabolizing it. I ate 10grams of powdered San Pedro cactus with Syrian Rue and the effects were very enjoyable.
Syrian Rue and hallucinogenic mushrooms is the best mix ever… The combination is frequently called Psilohauasca. Psilocin is a kind of DMT. It is DMT with a hydroxy(a hydrogen oxygen) bound at position 4 so it is 4HO-DMT or 4-Hydroxy-N,N-dimethyltryptamine. 4HO-DMT aka Psilocin metabolizes MUCH slower than DMT and Syrian Rue inhibits MAO which also destroys psilocin which is 4HO-DMT. The combination is profound and highly recommended. Mushrooms contain psilocybin which is mostly converted into psilocin when they mix with the hydrochloric acid in your stomach. To enhance them, soak them in lemon juice for 20 minutes which causes the psilocin to be created before you eat it which causes the onset to be more rapid and the effect better. The onset of Syrian Rue is also more rapid when consumed as a tea as opposed to eating whole seed. Rue, lemon and shrooms can be boiled together with 3 grams of passion flower leaf which also will enhance the effect by adding a 2nd MAOI that has a different bonding affinity to the MAO enzyme which metabolizes psilocin. Such is tea is Psilohuasca, serve it with “Golden Milk” which is turmeric and black pepper to be enhance it a little more.
Syrian Rue and marijuana are safe together, in fact marijuana may help with the nausea a little bit. Marijuana was historically called cannabis. In 1988 modern medical researchers discovered the cannabinoid receptors in the human body. Atleast 113 different cannabinoids have been discovered in the cannabis plant. Unlike the other plants discussed here which are water soluable, cannabinoids are fat soluble or lipid. Lecithin is a natural supplement which greatly enhances cannabis edibles by improving the emulsification of THC. As the MAOI enhances some things, lecithin greatly enhances cannabis – especially the edibles that about double in effect. Lecithin is an excellent source of choline, a B vitimin and metabolic precursor to acetylcholine.
Special Note about Datura, this plant is poision. Its worthy of digression. This plant is not a serotenergic psychedelic, in that it does not cause visions by 5HT receptors that bind serotonin and molecules based on a serotonin structure. It stops acetyl-choline. “To aid in the understanding cholinergic principles, consider Datura Stramonium from the nightshade family which is an anticholinergic agent, a substance that blocks the neurotransmitter acetylcholine. Classified as a deliriant, it causes bizarre behavior and pronounced amnesia somewhat imitating the conditions of Alzheimer’s by blocking acetlycholine. Contrast with cognition and memory enhancement suppliments that work by raising levels of acetylcholine. https://bodynutrition.org/acetylcholine
The effects from Datura poisoning generally last from 24-48 hours and in some cases, it can last 2 weeks.  The common-knowledge antidote is a reversible cholinesterase inhibitor, Physostigmine, interestingly – acquired from the poisonous Manchineel tree. ” from http://SyrianRue.org/Smart
When under the influence of datua you will not know what country your in or your name or if its a proper time to get naked. There are known incidents of purported Shamans that put it in an Aya brew where it has no place. Many self administtations of datura end up the the intensive care unit of hospitals.
LSD and Syrian Rue are safe together. LSD is almost natural considering that Lysergic acid amide, Lysergic acid propylamide, and other lysergamides exist in Hawaiian Baby Woodrose and in some varieties of Morning Glories, both plants of shamanic history.
Although MAOI related deaths do happen from drug interactions (not from food interactions), I have concluded that the dangers of using Syrian Rue as an MAOI are mostly overstated in an abundance of copy-paste-precaution that does not apply. Overstating dangers convolutes the truth. High levels of tyramine can cause blood vessels to narrow. This can lead to very high blood pressure, a severe headache, and possibly bleeding – a situation that possibly cannot happen with a reversible MAOI like Syrian Rue or only at very high doses. On lower MAOI doses you will find that many of the forbidden foods are safe in small quantities – as you increase the amount of Syrian Rue you take, you will discover that the dietary guidelines do become more important to follow and that they are not altogether irrelevant. In the spirit of caution in abundance, you should keep foods handy that are known to lower blood pressure in the event that you accidentally ingested enough tyramine to make you uncomfortable. Extra-virgin olive oil, Oregano, Hawthorn, Cardamom, Basil, Calamus Root, and Wandering Jew are all medicines that lower blood pressure.
I have carefully experimented with mixing the forbidden stimulants with Syrian Rue – start with caffeine. The dangers of being slightly under stimulant may be overstated. Caffeine is definitely potentiated, I like coffee with my ayahuasca. Many information sources state that caffeine is forbidden, however in light of the fact that Theobroma Cacao contains an MAOI and caffeine, the mixture of these two medicines is a natural powerful combination that can be mixed carefully.
Methamphetamine was marketed by pharmaceuticals as Methedrine, Pervitin and Desoxyn. A dose is between 5 and 30mg, nearly impossible to manage in its pure form. It was marketed for sinus relief, weight loss, and depression. Adderall is a mixed amphetamine salt very similar to or containing methamphetamine. There are probably 100’s of information sources that say methamphetamine or Addrerall cannot be mixed with an MAOI. Perhaps irreversible MAOI’s cannot but Syrian Rue can mix with Adderall. MAO metabolizes mono amines, hence the name, the amine is not mono(alone) if it is methylated which is why methamphetamine has a half life of 10.9 hours. The unmethylated amphetamine which was popular during the 1970s is metabolized by MAO which is why it has a shorter half life, it is a step closer to natural. The all natural ephedra is a stimulant stronger than caffeine however ephedra is a controlled substance initially because when it was legal it became popular in highschool sports where several overdoses were fatal and now it is a controlled substance mostly because it is a precursor to methamphetamine. Ephdra grows in Utah, and was brewed in a drink called Mormon Tea. Its disgusting compared to coffee and the all natural ephedra is slightly unnatural in its pure form. Doctor prescribed Vivance is extremely unnatural from a molecular structure view. Shulgin methylated mescaline and it became effective at 20mg rather than 200. MDA is essentially amimated(ammonia’d or NH(Nitrogen-Hydrogen) ) onto safrole which is the inexplicably sweet smelling essential oil of sassafras, safrole is also a controlled substance because it can be used as a precursor. You are not allowed to smell it. When MDMA was new it was often referred to as Methylated MDA. MDA is physically draining to the body and requires recovery time. MDA has visuals and a softer effect than MDMA however MDA REQUIRES you to drink excess water as it has killed people from overheating and dehydration – its not natural however its almost natural as 1 of the 10 aminated essential oils which becomes a neurotransmitter which is explained in detail in Pihkal and Tihkal.
Regarding iboga. Most entheogen resellers do not sell iboga. Its in a category of its own and requires special care and knowledge. It changes the signature of your heart beat as the ibogaine is metabolized into noribogaine. There are two schools of thought in use. One is a flood dose which causes a 48 hour experience with periods of panic/excitement with the visions and thought which has caused some deaths of heart attack however it has cured countless thousands of opiate addiction. The other school of thought uses gradual increments of 1g a few hours apart for days until a breakthrough is achieved – seemingly safer. Additionally, once the metabolite noribogaine is created and bound at neuro-receptors it has an incredibly long half life – remaining for weeks or months. Some amount of the lingering noribogaine is good however continued build up of noribogaine is bad and has hospitalized people. 60g per 6 months is a safe limit. These unusual (and little known) attributes cause iboga to be in a category of its own. The effect of Syrian Rue is “better” with a reasonable amount of noribogaine in your body which causes a small amount of rue to give the effect of a large amount that would otherwise require a nauseating amount of rue to achieve. Iboga done days prior to Ayahuasca will enhance the Aya experience. One reader commented on using a microdose of 1 to 1.5g of iboga at the same time as rue being a good synergy. I can recommend IbogaQueen.com as a knowledgeable handler of Iboga.
Note: Contrary to many information sources, Gin, Vodka, Rum, and Bourbon contain no tyramine so it is perfectly safe to mix a drink. You should not drink beer or wine with Syrian Rue due to the yeast in brewing however you can mix alcohol with Syrian Rue. Small amounts of alcohol were neither toxic nor had a magnified effect when tested on myself – still I generally do not mix them. Interestingly, when attempting to perform extractions of pure harmine/harmaline from Syrian Rue using either Methyl or Ethyl alcohols creates an inactive red harmala as opposed to an active water extracted yellow harmala. This same reaction could be happening in the body although that is pure speculation. More study needs to be done.
Smoking Syrian Rue, (http://SyrianRue.org/smoke ) in addition to eating it adds tremendous effect and is seemingly a different effect. For simplicity, put 2 oz of dry Rue seeds in a freezer ziplock and rub them together by rolling the bag between your hands, tip the bag to put a corner down and massage the seeds until the powder falls to the corner and smoke that. It has an immediate relaxing effect.
Dose – 1-2 grams is a low dose, 7 grams is a high dose. 50 to 100 grams will render you unconscious and is commonly used as an an effective emmenagogue and abortificient agent in some cultures.
To effectively inhibit MAO to the degree that you can feel the effects, I have had the best success by using low dosing orally and by smoke every 2-3 hours for periods of 12 hours, daily. If you experiment to this degree you will likely discover that if you use too much Rue, you will not realize it until 6 hours after you take the rue. I have woke up in the middle of the night seeing a slight visual effect known as rue trails. For my use, i prefer to be just below the point where visual changes begin – it can be a nausea free enjoyable experience to have slight visuals but a dose large enough to cause visual changes and remain nausea free – will require great attention to diet.
Many people merely intent to slow down the metabolism of psilocybin, DMT, or mescaline which can be accomplished with 1 small dose of rue 50 minutes prior to ingesting the neurotransmitters. Other people are trying to turn off MAO and leave it off long enough to build up natural neurotransmitters – which will require multiple doses..