MAOI antidepressants work by binding with monoamine oxidase(MAO) enzymes, thereby preventing them from breaking down monoamine neurotransmitters by oxidizing them. MAO destroys the neurotransmitters serotonin, substituted tryptamines (psychedelics), noradrenaline and dopamine, when MAO is inhibited by an MAOI those neurotransmitters accumulate unmolested at the receptor sites in the synaptic cleft resulting in increased levels of these natural organic neurotransmitters. This increase causes happiness ranging to “inappropriately happy” as first noted by researchers in 1950.

In 2016 Tranylcypromine is one of the most commonly prescribed MAOIs.  Tranylcypromine was originally developed as an amphetamine analogue and does have some amphetamine-like effects in addition to functioning as an MAOI.  Due to dietary interactions which apply more to pharmaceutical MAOIs than Syrian Rue, MAOI antidepressants are not prescribed as first line treatments.  Selective reuptake inhibiters and tricyclic drugs are generally prescribed before an MAOI.  MAOI antidepressants work more effective and reliable than any other antidepressant family in production today.  According to the Mayo Clinic, MAOI’s are used to relieve depression when other treatments have failed.  SSRI’s do not work well for many people.

Antidepressants are now prescribed not only for severe depression, but also for mild depression, anxiety, social phobia, and more.   In the US between the years 1989 and 1992, the number of prescriptions for antidepressants increased from 2.5 million to 33.2 million. That’s an increase of 1328%.  The rate of antidepressant overdose deaths increased more than 500 percent during the same time period.  In Germany, antidepressant use had risen 46% in just four years.  11% of Americans over the age of 12 take an antidepressant.  Antidepressants are trending.

SSRI antidepressants include: Prozac, Serafem, Zoloft, Paxil, Luvox, Celexa and Lexapro.
SNRI antidepressants include: Effexor, Remeron, Serzone and Cymbalta.
MAOI antidepressants include: Isocarboxazid (Marplan),  Phenelzine (Nardil), Selegiline (Emsam), Tranylcypromine (Parnate)

Some plants that contain an MAOI besides Syrian Rue are:  Passion Flower Vine, Cacao, Banisteriopsis Caapi, Coriander, Licorice root,  Rhodiola, and Ayahuasca.  Concentrates of these plants produce powerful effect.  Another great drink known as “Golden Milk”(1 serving is – 2 Table Spoons Turmeric , and 1/2 teaspoon of fresh ground/pulverized black pepper, any fat – a little butter or oil, fresh ginger and boil it for a while.  Drinking 2 servings is safe and good, 3 wont kill you.  Syrian Rue is effective in relatively small amounts – however the golden milk can be made to taste better than Syrian Rue tea.

There is now scientific proof that harmane, norharmane and harmine – all constituents of Syrian Rue are in fact MAOI antidepressants, you can reference the details of these research projects:

Harmine is a beta-carboline alkaloid that inhibits monoamine reuptake systems. Findings point to an antidepressant effect of the compounds that increases the levels of monoamines after monoamine oxidase inhibition.  Finally, these findings further support the hypothesis that harmine could be a new pharmacological target for the treatment of mood disorders.

Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009 Nov 13;33(8):1425-30. doi: 10.1016/j.pnpbp.2009.07.021. Epub 2009 Jul 24.

In a separate study it was concluded that harmane, norharmane and harmine produce an antidepressant-like effect, via an inverse-agonistic mechanism located in the benzodiazepine receptors.

European Neuropsychopharmacol. 2006 Jul;16(5):324-8. Epub 2005 Sep 22.
Farzin D, Mansouri N.